diff --git a/CHANGELOG.rst b/CHANGELOG.rst
index 424ea28f6596..785ae725d294 100644
--- a/CHANGELOG.rst
+++ b/CHANGELOG.rst
@@ -1,6 +1,13 @@
 Changelog
 =========
 
+.. _v50-0-0:
+
+50.0.0 - `main`_
+~~~~~~~~~~~~~~~~
+
+.. note:: This version is not yet released and is under active development.
+
 .. _v49-0-0:
 
 49.0.0 - 2026-06-12
diff --git a/Cargo.lock b/Cargo.lock
index c42be0dd2851..f7b6b9b9a3c9 100644
--- a/Cargo.lock
+++ b/Cargo.lock
@@ -53,7 +53,7 @@ checksum = "9330f8b2ff13f34540b44e946ef35111825727b38d33286ef986142615121801"
 
 [[package]]
 name = "cryptography-cffi"
-version = "0.49.0"
+version = "0.50.0-dev1"
 dependencies = [
  "cc",
  "openssl-sys",
@@ -62,21 +62,21 @@ dependencies = [
 
 [[package]]
 name = "cryptography-crypto"
-version = "0.49.0"
+version = "0.50.0-dev1"
 dependencies = [
  "openssl",
 ]
 
 [[package]]
 name = "cryptography-keepalive"
-version = "0.49.0"
+version = "0.50.0-dev1"
 dependencies = [
  "pyo3",
 ]
 
 [[package]]
 name = "cryptography-key-parsing"
-version = "0.49.0"
+version = "0.50.0-dev1"
 dependencies = [
  "asn1",
  "cfg-if",
@@ -90,7 +90,7 @@ dependencies = [
 
 [[package]]
 name = "cryptography-openssl"
-version = "0.49.0"
+version = "0.50.0-dev1"
 dependencies = [
  "cfg-if",
  "foreign-types",
@@ -101,7 +101,7 @@ dependencies = [
 
 [[package]]
 name = "cryptography-rust"
-version = "0.49.0"
+version = "0.50.0-dev1"
 dependencies = [
  "asn1",
  "base64",
@@ -124,14 +124,14 @@ dependencies = [
 
 [[package]]
 name = "cryptography-x509"
-version = "0.49.0"
+version = "0.50.0-dev1"
 dependencies = [
  "asn1",
 ]
 
 [[package]]
 name = "cryptography-x509-verification"
-version = "0.49.0"
+version = "0.50.0-dev1"
 dependencies = [
  "asn1",
  "cryptography-x509",
diff --git a/Cargo.toml b/Cargo.toml
index 06cb3f5a5694..540a19e4f089 100644
--- a/Cargo.toml
+++ b/Cargo.toml
@@ -12,7 +12,7 @@ members = [
 ]
 
 [workspace.package]
-version = "0.49.0"
+version = "0.50.0-dev1"
 authors = ["The cryptography developers <cryptography-dev@python.org>"]
 edition = "2021"
 publish = false
diff --git a/pyproject.toml b/pyproject.toml
index cddaf7fa8be7..9ee9b787a077 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -15,7 +15,7 @@ build-backend = "maturin"
 
 [project]
 name = "cryptography"
-version = "49.0.0"
+version = "50.0.0-dev1"
 authors = [
     { name = "The Python Cryptographic Authority and individual contributors", email = "cryptography-dev@python.org" },
 ]
@@ -75,7 +75,7 @@ dev = [
 ]
 nox = ["nox[uv] >=2024.04.15"]
 test = [
-    "cryptography_vectors==49.0.0",
+    "cryptography_vectors",
     "pytest >=7.4.0",
     "pytest-benchmark >=4.0",
     "pytest-cov >=2.10.1",
diff --git a/src/cryptography/__about__.py b/src/cryptography/__about__.py
index 2ae9fc7bc6ca..d6ac5fcc24d4 100644
--- a/src/cryptography/__about__.py
+++ b/src/cryptography/__about__.py
@@ -10,7 +10,7 @@
     "__version__",
 ]
 
-__version__ = "49.0.0"
+__version__ = "50.0.0-dev1"
 
 
 __author__ = "The Python Cryptographic Authority and individual contributors"
diff --git a/vectors/cryptography_vectors/__about__.py b/vectors/cryptography_vectors/__about__.py
index 88b7fcf43fdc..e150219a559f 100644
--- a/vectors/cryptography_vectors/__about__.py
+++ b/vectors/cryptography_vectors/__about__.py
@@ -6,4 +6,4 @@
     "__version__",
 ]
 
-__version__ = "49.0.0"
+__version__ = "50.0.0-dev1"
diff --git a/vectors/pyproject.toml b/vectors/pyproject.toml
index a8b5c3d91c63..e093b9a9b85f 100644
--- a/vectors/pyproject.toml
+++ b/vectors/pyproject.toml
@@ -6,7 +6,7 @@ build-backend = "uv_build"
 
 [project]
 name = "cryptography_vectors"
-version = "49.0.0"
+version = "50.0.0-dev1"
 authors = [
     {name = "The Python Cryptographic Authority and individual contributors", email = "cryptography-dev@python.org"}
 ]